Crestolip tablets are a new and effective oral medication that belongs to an important class of drugs known as statins, or HMG-CoA reductase inhibitors. Rosuvastatin, the active ingredient in Crestolip, is a powerful statin that primarily inhibits a key liver enzyme called 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme is responsible for a specific step in the process of cholesterol production in the liver. By inhibiting this enzyme, rosuvastatin reduces cholesterol production in the liver, leading to lower levels of "bad" LDL-C and total cholesterol in the blood. In addition, rosuvastatin may help lower triglyceride levels and slightly increase "good" HDL-C levels. Crestolip tablets are used as an essential part of a comprehensive treatment plan that also includes a healthy, low-fat, low-cholesterol diet, regular exercise, weight management, and smoking cessation. This helps treat high cholesterol and triglycerides and reduce the risk of atherosclerosis and serious cardiovascular diseases such as heart attacks and strokes.
The active ingredient in Crestolip tablets
Crestolip tablets contain the following active ingredient, which is the basis of its powerful therapeutic effect on blood lipid levels:
Rosuvastatin: A synthetic drug belonging to the statin group. Rosuvastatin is more effective at lowering harmful cholesterol (LDL-C) than some other statins. It works by competitively binding to the liver enzyme HMG-CoA reductase, preventing the conversion of HMG-CoA to mevalonic acid, a key compound in cholesterol synthesis. The reduced production of cholesterol within hepatocytes increases the number of LDL receptors on the surface of these cells, which increases LDL uptake from the blood and ultimately leads to lower LDL cholesterol levels in the circulation. In addition to its effect on LDL cholesterol, rosuvastatin may have other beneficial effects on blood lipid levels and other cardiovascular risk factors.
Available Strengths
Crestolip tablets are available in various strengths of rosuvastatin to meet the diverse therapeutic needs of patients and fit into different treatment plans developed by physicians based on initial cholesterol levels, response to treatment, and other risk factors. Common market strengths of Crestolip tablets include:
5 mg: This dose is often used for initiating treatment or as a maintenance dose in patients who require a modest reduction in LDL cholesterol or are at high risk of side effects.
10 mg: This dose is considered common for most patients with initially high cholesterol.
20 mg: This dose can be used for patients who require a greater reduction in LDL cholesterol or who have not responded adequately to lower doses.
40 mg: This is the highest recommended dose and is usually used only in patients with severe high cholesterol or homozygous familial hypercholesterolemia who require a significant reduction in LDL cholesterol levels.
The tablets are usually taken orally once daily. Rosuvastatin can be taken at any time of day, with or without food, as food does not significantly affect its absorption. However, it is recommended to take it at the same time each day to help you remember. The exact dosage is determined by your doctor based on a comprehensive assessment of your condition and target cholesterol levels. Your doctor may adjust the dosage periodically based on your response to treatment and the results of blood tests that measure lipid levels.