Co-valsartan tablets are an effective oral combination medication that combines two active ingredients that work synergistically to effectively control high blood pressure (hypertension) and reduce its associated risks. This medication contains valsartan, which belongs to a class of medications known as angiotensin II receptor blockers (ARBs), and hydrochlorothiazide, a thiazide diuretic. This combination lowers blood pressure through two different but complementary mechanisms, providing greater effectiveness in controlling high blood pressure than using either drug alone in many patients. Co-valsartan is an important treatment option for patients whose blood pressure is not adequately controlled with either drug alone, or when a combination of drugs is appropriate to achieve the therapeutic goal.
The active ingredient in Co-Valsartan tablets
Co-Valsartan tablets contain two active ingredients that work synergistically to target different mechanisms involved in blood pressure regulation:
Valsartan: A selective AT1 angiotensin II receptor blocker. Angiotensin II is a powerful hormone that causes blood vessels to constrict and increases aldosterone secretion, leading to high blood pressure and the body's retention of sodium and water. Valsartan works by blocking the binding of angiotensin II to these receptors, which leads to vasodilation and reduced aldosterone secretion, thereby lowering blood pressure and reducing the workload on the heart.
Hydrochlorothiazide: A thiazide diuretic that works by increasing the excretion of sodium and water from the body via the kidneys. This action reduces blood volume, thereby lowering blood pressure. In addition, over the long term, hydrochlorothiazide may also directly help dilate blood vessels.
These two medications work synergistically to lower blood pressure more effectively. Valsartan counteracts the effect of angiotensin II, while hydrochlorothiazide increases fluid and salt excretion from the body.
Available Strengths
Co-valsartan tablets are available in a variety of strengths that combine different doses of valsartan and hydrochlorothiazide to meet individual patient needs and achieve optimal blood pressure control:
Valsartan/hydrochlorothiazide: 80/12.5 mg: This strength may be used as a starting dose for some patients or as a maintenance dose for those requiring a lower dose.
Valsartan/hydrochlorothiazide: 160/12.5 mg: This strength is common for many patients requiring moderate blood pressure control.
Valsartan/hydrochlorothiazide: 160/25 mg: This strength provides a higher dose of diuretic to achieve greater blood pressure reduction.
Valsartan/Hydrochlorothiazide: 320/12.5 mg: This strength is used for patients who require a higher dose of an angiotensin II receptor blocker with a standard dose of a diuretic.
Valsartan/Hydrochlorothiazide: 320/25 mg: This strength represents the highest available strength and may be prescribed for patients with severe hypertension.
The appropriate combination and dosage are determined by a physician based on a careful assessment of the patient's blood pressure, response to initial treatment with either drug alone, general health, and any other medications they are taking. It is essential to strictly follow the physician's instructions regarding the dosage and timing of the medication and not change or discontinue it on your own. Co-valsartan is usually taken once daily.