Ezarpil tablets are an effective medication that belongs to the class of angiotensin-converting enzyme inhibitors (ACEIs). They contain the active ingredient enalapril maleate. Enalapril works by inhibiting the action of angiotensin-converting enzyme (ACE), an enzyme responsible for converting angiotensin I to angiotensin II in the body. Angiotensin II is a powerful substance that causes blood vessel constriction and the release of aldosterone, leading to high blood pressure and increased fluid and sodium retention.
By blocking the production of angiotensin II, Ezarpil tablets help treat high blood pressure by dilating blood vessels and reducing their resistance, making it easier for the heart to pump blood and lowering blood pressure. In addition, Ezarpil tablets are used to treat congestive heart failure by reducing the workload on the heart and improving its ability to pump blood more efficiently. It also plays an important role in protecting the kidneys in patients with diabetes (diabetic nephropathy) by reducing intraglomerular pressure and slowing the progression of kidney damage.
The active ingredient in Ezarpil tablets
Ezarpil tablets contain the following active ingredient, which is the basis of its therapeutic effect in regulating blood pressure, supporting the heart, and protecting the kidneys:
Enalapril Maleate: This medication belongs to the class of angiotensin-converting enzyme inhibitors (ACEIs). After oral administration, enalapril is converted in the liver to its active form, enalaprilat. Enalaprilat works by binding to the angiotensin-converting enzyme and blocking its activity, reducing the production of angiotensin II. This leads to vasodilation, lowering blood pressure, and reducing aldosterone secretion, which reduces sodium and water retention in the body.
Available Strengths
Ezarpil tablets are typically available in several strengths of enalapril maleate to provide flexibility in adjusting the dosage according to each patient's needs and response to treatment:
Enalapril maleate: 5 mg: Often used as a starting dose or maintenance dose for some patients, especially those with mild hypertension or early-stage heart failure.
Enalapril maleate: 10 mg: A common dose for many patients requiring moderate blood pressure reduction or to treat heart failure.
Enalapril maleate: 20 mg: Used for greater blood pressure reduction, to treat more advanced heart failure, or to protect the kidneys in diabetic patients.
The appropriate formulation and dosage of Ezrapil tablets are determined individually by the physician based on a careful assessment of the patient's medical condition, blood pressure level, kidney function, and the presence of any other medical conditions. Treatment is often started at a low dose and gradually increased until the therapeutic goal is achieved.
Indications for use of Ezarpil tablets
Ezarpil tablets are primarily used to treat and manage the following conditions:
Treatment of essential and secondary hypertension: Effective in lowering and controlling high blood pressure.
Treatment of congestive heart failure: Used to improve symptoms, reduce the risk of worsening, and prolong life in patients with heart failure.
Renal protection in diabetic patients with hypertension: Helps slow the progression of diabetic nephropathy and reduce the risk of kidney failure.