Medicine Description
About Pimozide Diphenylbutylpiperidine derivative, Antipsychotic, Antidyskinetic. Mechanism of Action of Pimozide Pimozide exerts its antipsychotic action by selectively inhibiting the Dopamine receptor. It also possesses weak antiadrenergic, antihistaminic, antiserotonin and anticholinergic actions. It also inhibits the reuptake of dopamine from the synaptic cleft Indications for Pimozide 1. Chronic psychoses 2. Gilles de la Tourette syndrome Interactions for Pimozide Anticonvulsants: Pimozide may lower the convulsive threshold. Phenothiazines, TCAs or Antiarrhythmic agents: Pimozide prolongs the QT interval, therefore avoid concomitant use. Alcohol and other CNS depressants (Hypnotics, Sedatives, Analgesics, Anxiolytics etc.): Pimozide potentiates the effects of these drugs.