Description : a non-steroidal anti-inflammatory drug (NSAID). Indication : Reducing pain and inflammation in conditions such as rheumatoid arthritis and osteoarthritis. Lower back pain. Reducing pain and inflammation following surgery. mechanism of action : Acemetacin works by blocking the action of a substance in the body called cyclo-oxygenase (COX). Cyclo-oxygenase is involved in the production of various chemicals in the body, some of which are known as prostaglandins. Prostaglandins are produced by the body in response to injury and certain diseases and conditions, and cause pain, swelling and inflammation. Acemetacin blocks the production of these prostaglandins and is therefore effective at reducing inflammation and pain