Co-Diovan tablets are a combination medication that represents an effective treatment strategy for controlling high blood pressure (hypertension), especially in cases where the patient does not respond adequately to treatment with either component alone. This medication contains a carefully considered and balanced combination of two active ingredients that work synergistically to achieve sustained blood pressure reduction: Valsartan 80 mg and Hydrochlorothiazide 12.5 mg.
Valsartan belongs to a group of medications known as angiotensin II receptor blockers (ARBs), which work by blocking the effect of the hormone angiotensin II, which causes blood vessel constriction and high blood pressure. Hydrochlorothiazide belongs to a class of drugs called thiazide diuretics, which work by increasing the excretion of sodium and water from the body through the kidneys, reducing blood volume and contributing to lowering blood pressure. This smart drug combination targets two different but complementary mechanisms in blood pressure regulation, making it an effective treatment option for many patients with high blood pressure.
The active ingredient in Co-Diovan tablets
Each Co-Diovan tablet contains an effective combination of two substances that work together to control high blood pressure:
Valsartan: A selective AT1 angiotensin II receptor blocker. Valsartan works by blocking the binding of angiotensin II to these receptors in blood vessels and other organs, leading to vasodilation and lower blood pressure. It also reduces the secretion of aldosterone, another hormone that contributes to high blood pressure.
Hydrochlorothiazide: A thiazide diuretic that works by inhibiting the reabsorption of sodium and chloride in the distal renal tubules, which increases water and sodium excretion and thus reduces blood volume and blood pressure. It also has a direct vasodilator effect.
Available Strengths
Co-Diovan tablets are available in a variety of formulations that combine different doses of valsartan and hydrochlorothiazide to provide flexible treatment options tailored to different patient needs and blood pressure levels:
Valsartan/hydrochlorothiazide: 80 mg/12.5 mg: This strength is often considered the starting dose for many patients with mild to moderate hypertension.
Valsartan/hydrochlorothiazide: 160 mg/12.5 mg: This strength is used for patients who require greater blood pressure reduction than a lower dose.
Valsartan/hydrochlorothiazide: 160 mg/25 mg: This strength provides a higher dose of the diuretic for a stronger blood pressure-lowering effect.
Valsartan/hydrochlorothiazide: 320 mg/12.5 mg and 320 mg/25 mg: These higher strengths are used for patients with more difficult-to-control hypertension. The appropriate dosage and formulation of Co-Diovan tablets are determined individually by the physician based on a careful assessment of the patient's blood pressure level, response to previous treatment (if present), kidney function, and other health conditions. Treatment is often started at a low dose and gradually increased until the blood pressure target is achieved.
Indications for Co-Diovan Tablets
Co-Diovan tablets are primarily used to treat essential hypertension (high blood pressure) in adults whose blood pressure is not adequately controlled with valsartan or hydrochlorothiazide alone. This medication is a suitable option for patients who require combination therapy to achieve the recommended blood pressure goals.